Eita enters high school aiming for the National University School of Medicine. Because of his parents’ divorce—and his goal—he shuns anything to do with romance or love. One day, Masuzu, the school beauty with the silver hair who has just returned to the country, enters his life in a most unexpected way. Chiwa, his childhood friend since elementary school, will not let this go without a fight.

Hitotose Chitose was always alone and untrusting of people but when 5 female teachers appear and started living together with him in his family’s house as his mothers, things started to change and pick up, together with Hazuki-nee and Minazuki (his 2 sisters) everyday is a lesson

Minato Sahashi is extremely intelligent, yet due to his inability to cope under pressure has failed the college entrance exam twice. As a result he has been branded an idiot and loser by many. One day after talking to his yet again disappointed mother he comes into contact with a girl named Musubi who was under attack. The girl runs but takes him with her and soon finds that Minato, while unknown to him, is an Ashikabi, one of the mysterious set of masters that have the genetic trait that can become partners with some of the 108 cute girls, buxom women, and bishounen called “Sekirei”. The reason for the partnership allows the Sekirei to use all their power to win in the competition held by the mysterious MBI corporation.

Komori Yui is a positive-thinking girl who nevertheless is troubled by seeing spirits and experiencing poltergeist phenomena. In her second year in high school, she transfers to a new school—a night school for entertainers and celebrities—due to her father’s work. There are rumours that vampires exist among the student body, and Yui ends up living with the six sadistic Sakamaki vampire brothers.